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CONJUGATES OF PLASMODIUM FALCIPARUM SURFACE PROTEINS AS MALARIA VACCINES

机译：恶性疟原虫表面蛋白作为疟疾疫苗的缀合物

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摘要

Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein Pvs25 for use as a vaccine against Plasmodium vivax are also provided. Methods for preparing the conjugates, which comprise the ookinete surface protein bound onto itself or onto another protein by a linking group, are also provided.

机译：提供了可共轭的表面蛋白Pfs25的结合物，可有效抵抗最严重的疟疾形式-恶性疟原虫。还提供了可作为间日疟原虫疫苗使用的ookinete表面蛋白Pvs25的缀合物。还提供了制备缀合物的方法，所述缀合物包含通过连接基团结合在其自身或另一种蛋白上的ookinete表面蛋白。 展开▼

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公开/公告号US2015050314A1

专利类型

公开/公告日2015-02-19

原文格式PDF

申请/专利权人 THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICE;
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申请/专利号US201414527676

发明设计人 RACHEL SCHNEERSON;JOANNA KUBLER-KIELB;YIMIN WU;LOUIS MILLER;FATHY MAJADLY;JOHN B. ROBBINS;
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申请日2014-10-29

分类号C07K14/445;

国家 US

入库时间 2022-08-21 15:23:52

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3. A FUSION PROTEIN MALARIA VACCINE CONSISTING OF PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 1 AND PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 3 [P] . IN282172B . 2017-04-07

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4. USE OF FUSION PROTEIN CONSISTING OF FRAGMENTS OF PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 1 AND PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 3 AS A MALARIA VACCINE [P] . IN2008DE01737A . 2010-04-23

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