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Methods of Predicting Clinical Outcome of Chronic Lymphocytic Leukemia
Methods of Predicting Clinical Outcome of Chronic Lymphocytic Leukemia
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机译:预测慢性淋巴细胞白血病临床结果的方法
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摘要
Provided are methods of predicting the outcome of a chronic lymphocytic leukemia (CLL) in a subject. The methods comprise performing a polymerase chain reaction assay for an IGH locus on a nucleic acid from a biological sample from a subject with CLL, wherein the PCR assay amplifies a non-coding region of the IGH locus, sequencing a product from the PCR assay, and determining a level of mutation in the non-coding region of the IGH locus. An increased level of mutation in the non-coding region as compared to a control indicates a positive outcome for the subject with CLL. A decreased level or no mutation in the non-coding region as compared to a control indicates a poor outcome for the subject with CLL.
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