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Treatment of heart disease by inhibition of the action of ribosomal S6 kinase 3 (RSK3)
Treatment of heart disease by inhibition of the action of ribosomal S6 kinase 3 (RSK3)
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机译:通过抑制核糖体S6激酶3(RSK3)的作用来治疗心脏病
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摘要
The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAPβ binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
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