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APPLICATION OF 2,9-DI-SEC-BUTYL-1,10-PHENANTHROLINE AS A GLIOBLASTOMA TUMOR CHEMOTHERAPY

机译:2,9-DI-SEC-BUTYL-1,10-菲咯啉在胶质母细胞瘤化疗中的应用

摘要

A method of inhibiting cancer cell growth is provided. In some versions, the method includes exposing lung cancer cells or glioma cells to 2,9-di-sec-butyl-1,10-phenanthroline (SBP) or derivatives of SBP in an amount effective to inhibit glioma cell growth. Also, a method of treating a lung cancer or a glioma tumor in a subject in need of such treatment is provided. The method includes administering SBP or derivatives of SBP to the subject in an amount effective to treat the lung cancer or glioma tumor. For either method, the method can further include exposing or administering pseudo five coordinate gold(III) complexes of SBP derivatives.
机译:提供了一种抑制癌细胞生长的方法。在一些版本中,该方法包括将肺癌细胞或神经胶质瘤细胞暴露于有效抑制神经胶质瘤细胞生长的量的2,9-二仲丁基-1,10-菲咯啉(SBP)或SBP衍生物。另外,提供了一种在需要这种治疗的受试者中治疗肺癌或神经胶质瘤肿瘤的方法。该方法包括以有效治疗肺癌或神经胶质瘤肿瘤的量向受试者施用SBP或SBP衍生物。对于任一种方法,该方法可以进一步包括暴露或施用SBP衍生物的假五配位金(III)配合物。

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