METHODS OF TREATING AMYLOIDOSES WITH VITAMIN B12 AND DIAGNOSTIC TEST FOR DETECTING THE PRESENCE OF AMYLOID-BETA PEPTIDES

摘要

Embodiments of the invention include methods of using vitamin B12 to influence amyloid-beta peptide aggregation. A preferred method comprises contacting at least one amyloid-beta peptide oligomer formed from a plurality of amyloid-beta peptide monomers with an effective amount of vitamin B12, the effective amount being sufficient to stimulate dissociation of the amyloid-beta peptide monomers from the amyloid-beta peptide oligomer or fibril. Also provided are methods of treating Alzheimer's disease and diagnostic tests for detecting the presence of amyloid-beta peptides.