METHOD FOR ENHANCING ANTI-TUMOR EFFECT OF A MICROTUBULE-TARGETING DRUG, AND A METHOD FOR TREATMENT OF TUMOR

摘要

A method for treating a tumor by combining a piperidine compound of formula (I) or salt thereof and a microtubule-targeting drug, in which the microtubule-targeting drug is administered once per 7 days or more one cycle, and the piperidine compound is administered once or more per day for 4 days or more:; R₁ represents a carboxyl group, —C(═O)NR₅R₆, or an oxadiazolyl group optionally substituted with a C₁-C₆ alkyl group or trifluoromethyl group; R₂ represents a halogen atom or C₁-C₆ alkoxy group; R₃ represents a phenyl group optionally having 1 to 3 groups, selected from a halogen atom, and a C₁-C₆ alkyl, C₁-C₆ alkoxy, or trifluoromethyl group; R₄ represents a hydrogen atom or C₁-C₆ alkyl group; and R₅ and R₆, each represent a hydrogen atom, a C₁-C₆ alkyl or C₃-C₆ cycloalkyl group; or R₅ and R₆, together with a nitrogen atom, optionally form a 3 to 6-membered nitrogen-containing saturated heterocyclic group.