Method and apparatus for estimating cerebral cortical source activations from electroencephalograms

摘要

Methods and apparatuses for estimating activation of cerebral cortical sources from scalp site measurements of electroencephalograms (EEG) from a human subject are provided. In an exemplary embodiment, a method comprises: specifying cortical neural sources within the brain of the subject; simulating activation potentials for the specified cortical neural sources; projecting the simulated cortical neural source voltage activations to scalp site measurements locations for the subject; simulating scalp voltage potentials for one or more extra-cranial sources outside the brain; constructing simulated scalp site voltage potentials from the projected simulated modeled cortical neural source voltage activations and the simulated extra-cranial scalp voltage potentials; comparing the simulated scalp site voltage potentials and the electroencephalograms scalp site measurements for the subject; and adjusting parameters for simulating the cortical neural source voltage activations until the simulated scalp site voltage potentials generally correspond to the electroencephalograms scalp site measurements based on the comparison.