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Nanopore-Based Single DNA Molecule Characterization, Identification and Isolation Using Speed Bumps
Nanopore-Based Single DNA Molecule Characterization, Identification and Isolation Using Speed Bumps
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机译:基于纳米棒的单分子DNA分子特征,鉴定和使用减速带的分离。
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摘要
The present invention relates to a method of using nanopores to obtain sequence information of sample DNAs in ss test DNAs. The method comprises using speed bumps to stall the ss test DNAs in the nanopores at random positions of the ss test DNAs to obtain sequence information of each and every nucleotides of the sample DNAs, and to construct the whole sequences of the sample DNAs. The present invention also relates to identification and/or isolation of test DNAs having desired sequence(s) using nanopore detectors facilitated by speed bump.
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