Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof

摘要

Acridine containing cisplatin compounds have been disclosed that show greater efficacy against cancer than other cisplatin compounds. Methods of delivery of those more effective cisplatin compounds to the nucleus in cancer cells is disclosed using one or more amino acids, one or more sugars, one or more polymeric ethers, C_1-6alkylene-phenyl-NH—C(O)—R₁₅, folic acid, α_vβ₃ integrin RGD binding peptide, tamoxifen, endoxifen, epidermal growth factor receptor, antibody conjugates, kinase inhibitors, diazoles, triazoles, oxazoles, erlotinib, and/or mixtures thereof; wherein R₁₅ is a peptide.