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Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
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机译:用于局部递送非甾体抗炎药以减轻肌肉骨骼疼痛的凝胶及其制备方法
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摘要
A drug-delivery system is described which can serve as a platform for the topical delivery of a wide variety of therapeutic agents to the skin. Specifically, a topical external analgesic gel contains ketoprofen, a skin penetration enhancer/cosolvent, a thickening agent and a base to adjust pH. The formulation uses a relatively small number of safe components and is easy to prepare with a high yield of finished product. The chemical stability of ketoprofen in the gel and the physical stability of the gel itself ensure a satisfactory shelf-life for the product. The gel is aesthetically pleasing (i.e., easy water-washability, non-irritating to skin, non-staining of clothing, etc.) and has proven to provide rapid relief of musculoskeletal pain, thereby helping to ensure patient compliance.
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