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Benzofuro3,2-c pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
Benzofuro3,2-c pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
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机译:Benzofuro [3,2- c I>]吡啶和相关类似物作为5-羟色胺亚型6(5-HT 6 Sub>)调节剂,用于治疗肥胖症,代谢综合征,认知障碍和精神分裂症
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摘要
The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I); with the substituents being described herein.
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