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Use of C-terminal domain of IGFBP-5 comprising heparin-binding domain as an angiogenesis inhibitor
Use of C-terminal domain of IGFBP-5 comprising heparin-binding domain as an angiogenesis inhibitor
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机译:包含肝素结合结构域的IGFBP-5的C末端结构域作为血管生成抑制剂的用途
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摘要
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis comprising an isolated peptide comprising the heparin-binding domain of insulin-like growth factor-binding protein-5 (IGFBP-5), a method for inhibiting angiogenesis using the peptide, a pharmaceutical composition for the prevention or treatment of cancer comprising the peptide, a method for treating cancer using the peptide, a novel angiogenesis-inhibiting peptide derived from heparin-binding domain of IGFBP-5, a polynucleotide encoding the peptide, an expression vector comprising the polynucleotide and a transformant comprising the vector.
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