首页>
外国专利>
Differentiated human liver cell cultures and their use in bioartificial liver systems
Differentiated human liver cell cultures and their use in bioartificial liver systems
展开▼
机译:差异化人类肝细胞培养及其在生物人工肝系统中的应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to temporarily compensate for loss of hepatocellular function and generally comprise a bioreactor loaded with functional liver cells. Until now, it has been problematic to acquire cells with a broad spectrum metabolic functionality, resembling that of freshly isolated human hepatocytes, to the extent that they are in fact suitable for successful clinical BAL application The present inventors have managed to develop human hepatocyte cell line cultures that display broad-spectrum metabolic functionality such as to render them particularly suitable for effective clinical BAL application.
展开▼