Methods for treating diabetes by administering a Glucagon Receptor Antagonist in combination with a cholesterol Absorption Inhibitor, Combination

摘要

Use of a Glucagon Receptor Antagonist in combination with a cholesterol Absorption Inhibitor for the treatment of Diabetes and Related Conditions.Claim 1: a method to treat diabetes in a subject comprising administering to said Mammal Mammal subject: (a) a Glucagon Receptor Antagonist, and (b) a cholesterol Absorption Inhibitor; in which the subject Mammal has a level of LDL Cholesterol in plasma Less than 130 mg / dl.Claim 8: any method of claims 1 - 7 in which the compound inhibitor of cholesterol Absorption is formula (1) or a pharmaceutically acceptable Salt thereof.Claim 9: any method of claims 1 - 8 in the Glucagon Receptor Antagonist Compound is a compound selected from compounds (Table 2); or a pharmaceutically acceptable Salt of the same.