Emzima amp CoA ligase active luciferase (zophobas Morio), developed by engineering genetics, process to implement the activity luciferu00e1sica in amp COA ligases, process of luminescent activity inhibition of protoluciferase for pre selection and bioprospecu00e7u00e3o substrates carboxu00ed Licos biosensor cell and pharmaceutical composition.

摘要

The enzyme amp CoA ligase active luciferase (zophobas Morio), developed by genetic engineering process to implement the activity luciferu00e1sica in amp COA ligases, process of luminescent activity inhibition of protoluiferase for pre selection and bioprospecu00e7u00e3o substrates carboxu00edl ICOS biosensor cell and pharmaceutical composition.It is described a new enzyme amp CoA ligase with properties of luciferase ATP for the purpose of detoxification it and excretion of xenobiotics. The enzyme is use in detoxification it and excretion of xenobiotic organic substrates, and potential target of pharmaceutical drugs and pesticides, is useful in the identification process of the enzyme.The development of a new luciferase from this enzyme, with the properties of luminescu00eania comparable to traditional luciferases beetles in the presence of D - Firefly luciferin of ATP, a technique to implement the activity luciferu00e1sica in amp COA ligases through mutagenesis Si Uncle - directed, a biosensor cell and a pharmaceutical composition are also described.