首页>
外国专利>
indazoles as inhibitors of the wnt / b-catenin signaling pathway and their therapeutic uses.
indazoles as inhibitors of the wnt / b-catenin signaling pathway and their therapeutic uses.
展开▼
机译:吲唑类作为wnt / b-catenin信号通路的抑制剂及其治疗用途。
展开▼
页面导航
摘要
著录项
相似文献
摘要
Described herein are methods of treating a disorder or disease in which aberrant Wnt signaling is implicated, with a variety of compounds, including Wnt inhibitor compounds. More particularly, it concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components.
展开▼