Methods and compositions for treating disorders of the nail and nail bed. Such compositions do not form a film upon application to the surface of the nail and contain a vehicle in which all components of the compositions are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.
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