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Topical ophthalmic pharmaceutical composition comprising fluoroquinolone derivatives for ophthalmic applications and use thereof
Topical ophthalmic pharmaceutical composition comprising fluoroquinolone derivatives for ophthalmic applications and use thereof
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机译:用于眼科应用的包含氟喹诺酮衍生物的局部眼科药物组合物及其用途
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摘要
The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity.
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