Floating systems gastrorrentensivos release prolonged to develop drugs soluble in water easily.

摘要

Floating systems gastrorretensivos release prolonged to develop drugs easily soluble in water. The systems gastrorretensivos floating release modified, effervescent tablets, are presented as a rational approach to modulate the release of drugs in the gastrointestinal tract.This technology is a breakthrough in the therapy of drugs that act or should be absorbed in the stomach or the duedeno proximally. Reduce the loss of biological drug, allowing the reduction of the therapeutic dose and the final cost of the product. The technical procedure used for the preparation of granules gastrorretensivos floating can be carried out in different scales of production.The process involves simple unit operations in common equipment of the praxis pharmaceutical, which facilitates the implementation of scale. The product obtained can be aired both in the pharmaceutical form of tablet and capsules. This versatility increases the industrial interest for this technological innovation.