Process for the preparation of 1 - 6 - (4 - (amp; mdash; il) pyrimidin-4-yl - 4 - (1H - 1,2,3 - triazol 1 - il) - 1H pyrazole - 5 - ol (I amp; ndash; Enol form) or 2 - 6 - ((- 4-yl) pyrimidin-4-yl - 4 - (1H - 1,2,3 - triazol 1 - il) - 1,2 - dihydro 3h pyrazole - 3-one (I amp; ndash; Keto form and Compound intermediary (2E); / (Z) - 3 - (dimet Ilamino) - 2 - (1H - 1,2,3 - triazol 1 - yl) Methyl acrylate.

摘要

The present invention relates to a process for preparing 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-ol (I—enol form) or 2-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one (I—keto form) and sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate (II) from 1,2,3-triazole (III), methyl bromoacetate (IV-Me-Br) or ethyl bromoacetate (IV-Et-Br), 4,6-dichloropyrimidine (VIII), morpholine (IX) and hydrazine (XII).