2. Bisexual antibodies, including endocrine vascular growth factor (VEGF) and angiopoietina-2 (Ang-2) and mutation i253a / h310a / h435a; pharmacological synthesis; acid nucleic acid; vectors; cells; production methods; drugs for the treatment of ocular vascular diseases.

摘要

The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.