Tricyclic FUSED thiophene Compounds, inhibitors of Janus Kinase (JAK); Pharmaceutical composition that comprises; a method for inhibiting the activity of JAK1; a method for treating an autoimmune disease, cancer, a myeloproliferative disorder and Disease inflamat Oria, among other diseases.

摘要

The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.