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Amorphous solid dispersion comprising a Derivative of tetrazol; Pharmaceutical composition that comprises Pharmaceutical Combination; use; to reduce multidrug resistance in cancer cells.
Amorphous solid dispersion comprising a Derivative of tetrazol; Pharmaceutical composition that comprises Pharmaceutical Combination; use; to reduce multidrug resistance in cancer cells.
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机译:包含四唑衍生物的非晶态固体分散体;包含药物组合的药物组合物;采用;降低癌细胞的多药耐药性。
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摘要
The present invention relates to an amorphous solid dispersion comprising a tetrazole derivative of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The solid dispersion of the present invention comprises a water-soluble polymer or an acid so as to improve the solubility of its active ingredient, i.e., the tetrazole derivative of the formula (I), thereby improving its absorption rate, and thus can be effectively used to reduce multi-drug resistance (MDR) in cancer cells.
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