Physically Stable Solid dispersion of acid, 4 - (2R, 3S, 4R, 5S) - 4 - (4 - chlorine - 2-fluorophenyl) - cyano - 4 - 5 - (- 2.2 - dimetilpropil pyrrolidin-2-one) carbonyl amino} - 3 - metoxibenzoico Solid; formulation; Preparation method; Pharmaceutical Preparation; use to treat Cancer, in particular to myeloid leukemia Guda or prostate cancer.

摘要

The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds.