Compounds 4 - {7 - methyl - 3 - oxo - 8 - 3 - (trifluoromeil cyclohexa-2,5-dien-1-ylidene) - 2.4 - dien - triazin-1-yl 2,3,5,8 - tetrahydro - 1,2,4 triazolo 4,3-a pyrimidin-5-yl) benzonitrile; Pharmaceutical composition; a method for treating a disease or a condition in which participating hne, such as COPD, pneumonia, Asthma, rhinitis, and Among others.

摘要

Pyrimidinone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HINE is implicated.