It limits the number of pion, ORL1, and P1.

摘要

The present invention relates to a kind of receptor ligand containing some limited amino acids, which is advantageous to the formation of delta_alpha____________96 HX alpha helix or beta wide clones. Preferably, the ORL-1 receptor ligand has one or more segments of the present invention "delta_epsilon____residues to form alpha_uuuuuuuuuuu Let's.The ligands of the invention include ORL-1 receptor agonists, which can be used as analgesics for treating pain in one patient. - who needs such a treatment, can also be used to treat anxiety, addictive drugs withdrawal and tolerance, as well as in Equality enhances memory and learning.