The reduction of amyloid-beta burden in tissues that are not derived from brain

摘要

The present invention relates to methods and compositions for modulating levels of amyloid- peptide (A) exhibited by non-neuronal (i.e., peripheral) cells, fluids, or tissues. The invention also relates to modulation of A levels via selective modulation (e.g., inhibition) of -secretase activity. The invention also relates to methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an A-related disorder, by administering a compound that result in the modulation of -secretase in a non-neuronal tissue, either directly or indirectly to prevent, treat or ameliorate the symptoms of a brain A disorder, such as Alzheimer's disease.