CDK8 / CDK19 SELECTIVE INHIBITORS AND THEIR APPLICATION AS ANTI-METASTATIC AND CHEMICAL PROPHYLACTIC AGENTS FOR THE TREATMENT OF CANCER

摘要

The invention relates to compounds and methods for inhibiting the cyclin-dependent kinase metabolic pathway (CDKI). In particular, the invention relates to compounds and methods for inhibiting the CDKI pathway for the investigation and treatment of diseases associated with aging and other CDKI-associated processes. The invention proposes new compounds with increased solubility and / or efficiency, and methods for their use. In various aspects, the invention relates to the treatment of cancer. The invention provides methods for chemoprophylaxis and preventing the recurrence of tumors or metastases. In addition, the invention provides diagnostic tools for the treatment of certain types of cancer. Methods of use according to the invention involves the administration of specific inhibitors of CDK8 / 19 and / or the measurement of CDK8 levels in a patient.