SYNTHETIC MIMETICS OF APELIN FOR THE TREATMENT OF HEART FAILURE

摘要

The invention relates to a synthetic polypeptide of the formula I'or its amide, ester or salt, where X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined in the present description. The polypeptides are an APJ receptor agonist. The invention also relates to a method for producing polypeptides of the invention and its therapeutic use, such as the treatment or prevention of acute decompensated heart failure (ODSN), chronic heart failure, pulmonary hypertension, atrial fibrillation, Bruggad syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmias, fluid retention, diabetes (including gestational diabetes), ozh rhenium, peripheral artery disease, cerebrovascular disorders, transient ischemic attacks, traumatic brain injury, amyotrophic lateral sclerosis, burn injuries (including sunburn) and pre-eclampsia.