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5-substituted- pyrimidine-2,4-diamimes, pharmaceutical compositions comprising them and their use in the manufacture of a medicament for treatment of p2x3 and p2x2/3 recepror mediated disease
5-substituted- pyrimidine-2,4-diamimes, pharmaceutical compositions comprising them and their use in the manufacture of a medicament for treatment of p2x3 and p2x2/3 recepror mediated disease
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
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机译:式I化合物或其药学上可接受的盐,其中A,D,E,G,J,X,Y,Z R 6,R 7和R 8如本文所定义。还提供了使用所述化合物治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的方法和制备所述化合物的方法。
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