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Combinations of activated cytotoxic t lymphocytes, cytokines and cladribine for treating cancer
Combinations of activated cytotoxic t lymphocytes, cytokines and cladribine for treating cancer
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机译:活化的细胞毒性t淋巴细胞,细胞因子和克拉屈滨的组合治疗癌症
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摘要
In a cancer treatment combining cell therapy with chemotherapy, autologous CD8+ T cells are obtained from a patient, activated ex vivo by contacting them with xenogenic antigen presenting cells loaded with selected peptide antigen, thereby generating antigen-specific activated cytotoxic T lymphocytes. Such activated CTLs are administered to the patient in conjunction with a lymphodepletion and CTL maintenance regimen comprising a non-myeloblative but lymphdepleting agent, such as cladribine or denileukin diftitox, and interleukin-2 and interferon--2b stimulatory cytokines.
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