A cytolytic rtx-toxin from gallibacterium anatis

摘要

The present invention relates to the field of animal health and in particular the causative agent of a new bacterial poultry disease caused by Gallibacteruim spp, including Gallibacterium anatis, Gallibacterium genomospecies 1 and Gallibacterium genomospecies 2. The invention provides a novel RTX toxin from said Gallibacterium species, the novel toxin being named GtxA (Gallibacterium toxin). In addition the invention provides the amino acid and nucleotide sequences of GtxA, a vaccine comprising inactivated toxoid or fragments of the toxoid as well as methods of immunizing birds to prevent said disease and to methods of diagnosing a Gallibacterium anatis infection in birds.