RECOMBINANT STRAIN OF MYCOBACTERIUM BOVIS BACILLUS CALMETTE GUERIN (BCG) IMMUNOGENIC COMPOSITION AND USE

摘要

The present invention relates to recombinant strains ofthat encode the mutated LT heat labile toxin or the A subunit of the mutated LT heat labile toxin. The present invention also relates to strains of that encode the LT heat labile toxin or the A subunit of the LT heat labile toxin of mutated in position 63. Specifically the present invention relates to strains of that encode the LT heat labile toxin or the A subunit of the LT heat labile toxin of mutated in position 63 from serine to lysine. The present invention also provides immunogenic compositions that comprise the strains of the present invention. The present invention further provides for the use of said strains and immunological compositions in the production of a vaccine for preventing tuberculosis and infections caused by Lastly the present invention relates to methods for preventing or treating tuberculosis in animals.