ANALGESIC COMPOSITION OF TOPICALLY APPLIED NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND OPIOIDS

摘要

The present invention relates to pharmaceutical formulations comprising at least two compounds, one effecting opioid analgesia and one effecting cyclooxygenase 1 and 2 activity, in amounts sufficient to potentiate an antinociceptive response when both compounds are topically administered in a physiologically acceptable topical excipient. The pharmaceutical formulations of the present invention are used to prevent or relieve acute pain and chronic peripheral neuropathy and/or neuropathic inflamma¬tion in a patient in need of such treatment.