PROCESSES FOR PRODUCING 6-0-PALMITOYL-3-0-BETA-P-D-GLUCOPYRANOS YL-CAMPESTEROL, EXTRACTS AND FRACTIONS, FROM THE WILD-TYPE PLANT AND IN VITRO CULTURES OF LOPEZIA RACEMES CAV., AND THE APPLICATION THEREOF AS ANTI-INFLAMMATORY AGENTS IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS.

摘要

The invention relates to the method for producing the compound 6-0-palmitoyl-3-0-[beta]-P-D-glucopyranosyl-campesterol(6-O-PGC) with a novel structure and with in vivo anti-inflammatory activity, from plant extracts obtained from in vitro cultures and wild-type plants of Lopezia racemosa. The invention also relates to the method for producing extracts and fractions with anti-inflammatory activity, obtained from in vitro cultures and wild plants of Lopezia racemosa with different organic solvents, and to the use of said extracts as anti-inflammatory agents.; The invention further relates to the application of the extracts which contain, as active principle, 6-0-palmitoyl-3-0-[beta]-D-glucopyranosyl-campesterol (6-O-PGC), and extracts or fractions of Lopezia racemes, for the effective treatment of inflammatory disorders, in various pharmaceutical or cosmetic compositions formulated for the oral or topical administration thereof. Another aim of the invention is to use the biotechnologica l process in order to improve the yield of the anti-inflammatory active principles and to establish an alternative for obtaining plant material via the micropropagation of the plant Lopezia racemosa. This process includes the production of axenic seedlings by means of in vitro germination, and the direct and indirect induction of morphogenesis.