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A method for the treatment of a solid tumour

机译:一种实体瘤的治疗方法

摘要

Disclosed herein is the use of two separate formulations of a particulate material, and a cellular toxin, effective to penetrate a solid tumour and induce cytotoxicity, in the manufacture of a medicament for the treatment of a solid tumour, wherein said particulate material is in the form of a dispersion in a liquid carrier, the particulate material being maintained in the dispersed state by a steric stabiliser; wherein said steric stabiliser comprises an anchoring portion and a steric stabilising polymeric segment, wherein the anchoring portion is different from the steric stabilising polymeric segment; and wherein the anchoring portion has an affinity towards the surface of the particulate material and secures the stabiliser to the particulate material.
机译:本文公开了颗粒材料和细胞毒素的两种分开的制剂在制备用于治疗实体瘤的药物中的用途,所述制剂有效地穿透实体瘤并诱导细胞毒性,其中所述颗粒材料在皮肤中。分散在液体载体中的形式,颗粒材料通过空间稳定剂保持在分散状态;其中所述空间稳定剂包括锚定部分和空间稳定聚合物链段,其中所述锚定部分不同于所述空间稳定聚合物链段;其中锚固部分对颗粒材料的表面具有亲和力,并将稳定剂固定在颗粒材料上。

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