Shon as a prognostic biomarker for cancer and as a predictor of response to endocrine therapy

摘要

Discloses a method of predicting responsiveness to endocrine therapy of a tumour, which comprises identifying the presence of a SHON (HIP-1) polypeptide, wherein the SHON polypeptide comprises an amino acid sequence substantially similar to SEQ ID NOs: 2, 5 and 6 and where the presence of SHOT indicates that the tumour is endocrine therapy-responsive. It further discloses a kit comprising at least one antibody or DNA primer for SEQ ID NOs: 2, 5 and 6, a reagent comprising an antibody or DNA primer for SEQ ID NOs: 2, 5 and 6, the isolated SHON polypeptide of SEQ ID NOs: 2, 5 and 6 and an isolated polynucleotide of SEQ ID NOs: 2, 5 and 6. Wherein the SEQ ID NO: 6 is the N-terminal of SEQ ID NO: 5 and is MDRMASSMKQ VPNPLPKVLS RRGVGAGLEA AERESFERTQ TSLAYLLLPA SSRKPCLLNSPAPSSHFTWP LSLPEEAPLT CLMAQPLHPS PTRPLVCSPP NPSQATFKL