Mixed papillary fish of conch and non conch

摘要

The invention relates to compounds of general formula (I), wherein R1, R2, u, V, l, m, R5, m, x, y and Z are defined here, and the pharmaceutically acceptable salts include these compounds and salts; in addition, these compounds are modulators of EZH2 activity, so they can be used for Treatment of abnormal cell growth, including cancer