Method for Identifying the Origin of a cancer of unknown Primary origin

摘要

Refers to methods and Reagents for the identification of the Origin of a carcinoma of unknown Primary origin (CPD) based on the determination of methylation profile in the Genome of the CPDWherein the method comprises: a) determine the methylation profile in a selected region of a DNA isolated from the CPD; and (b) compare the methylation Profile of the selected region with the methylation Profile of the same region in a DNA Sample isolated from a primary tumor.(i) also refers to methods for selecting appropriate Therapy for a patient who suffers from a CDP, (ii) Methods for Personalized Medicine for patients suffering from a CPD based on the use of a treatment that is suitable for the primary tumor that derives the CPD, (iii) kits that com The Reagents are suitable for the methods above,And (iv) systems and computer programs to implement these methods.