Biodegradable, polymer system for the local releasing of medicine to be used in the treatment of parodontium diseases and method for producing it

摘要

biodegradable, polimerowy system local release drug for use in treatment of periodontal diseases, as wysokoelastyczne, composite plates in the form of a mechanically strong typoszeregu, rings and / or oval of the dimensions of which are related to the construction of anatomiczn s and the size of human teeth is suchthat is a composite made from polymer matrix; forming the biodegradable aliphatic and aliphatic polycarbonates and biokompatybilne poliestrowu0119glany or / and their mixture, preferably poly (e - caprolactone - what - trimethylene carbonate) content of kaproilu from 30 to 85 mole% or / and acyclic p oliwu0119glany,poly (trimethylene carbonate beneficial - what - carbonate neopentyl diphosphite) content of comonomer trimetylowu0119glanu from 50 to 90 mole%, preferably obtained in the synthesis of the method eliminating the presence of toxic metals in the final product, with the filler zdyspergowanym or / and rozpus zczonym in matrix is antibiotic soluble in water; preferably with tetracyclines (tetracycline, groupdoxycycline); or / and the tcp, preferably chlorhexidine or / and metronidazole or / and triclosan, and not be content ranges from 5% to 30% by weight of the total weight of composition, preferably from 10 weight percent to 20% by weight, and is chosen so as to ensure at the same time, respectively. high concentration of released drug in the pocket dziu0105su0142owej,to eliminate pathogenic bacteria which cause diseases, while maintaining satisfactory flexibility and mechanical strength composite, which allows for easy, rapid and positive retention system.the subject of the invention is also a way of system of listed component substances and its application, without the necessity of removing system with pocket dziu0105su0142owej.