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COMPOSITIONS COMPRISING AN AP2-SPECIFIC ANTIBODY OR A FRAGMENT THEREOF FOR USE IN TREATING DIABETES, GLUCOSE INTOLERANCE OR OBESITY-INDUCED INSULIN RESISTANCE
COMPOSITIONS COMPRISING AN AP2-SPECIFIC ANTIBODY OR A FRAGMENT THEREOF FOR USE IN TREATING DIABETES, GLUCOSE INTOLERANCE OR OBESITY-INDUCED INSULIN RESISTANCE
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机译:包含AP2特异性抗体或其片段的组合物,用于治疗糖尿病,糖耐量异常或肥胖引起的胰岛素抵抗
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摘要
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.
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