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peptides derived from fviii and their use in immunological tolerance in hemophiliacs
peptides derived from fviii and their use in immunological tolerance in hemophiliacs
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机译:fviii衍生的多肽及其在血友病患者免疫耐受中的应用
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摘要
The present invention provides peptides at least partly derivable from FVIII which are capable of binding to an MHC class II molecule without further antigen processing and being recognised by a factor VIII specific T cell. In particular, the present invention provides a peptide comprising or consisting of the sequence EDNE4VTFRNQASR. The present invention also relates to the use of such a peptide for the prevention or suppression of inhibitor antibody formation in haemophilia A and/or acquired haemophilia.
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