CURCUMIN-ER, A NANOCURCUMIN FROM LIPOSOMAL PLGA WITH CONTINUED RELEASE TO MINIMIZE QT EXTENSION TO CANCER THERAPY

摘要

The present invention includes compositions and methods of making a nanoparticle composition comprising a polymeric core containing at least one polymer and at least one active agent and at least one layer of at least one lipid on the surface of the polymeric core; In particular, the invention relates to the use of curcumin in such a lipid-polymer nanoparticle formulation to minimize QT prolongation associated with curcumin in the treatment of cancer.