Compositions and methods to stabilize transthyretin and inhibit the abnormal folding of transthyretin

摘要

A method of screening a compound that prevents or reduces the cleavage of a transthyretin tetramer, said method comprising: contacting a transthyretin tetramer with a candidate compound; and determining whether the candidate compound increases the activation energy associated with dissociation of the transthyretin tetramer, thereby preventing or reducing dissociation of the transthyretin tetramer.