首页> 外国专利> Prepared phase stable and sedimentation, plastically deformable, with intrinsic pore formation, intended, for example, for filling bone defects or for use as a bone substitute material, and method for its production.

Prepared phase stable and sedimentation, plastically deformable, with intrinsic pore formation, intended, for example, for filling bone defects or for use as a bone substitute material, and method for its production.

机译:所制备的相稳定和沉降,可塑性变形,具有固有的孔形成,例如用于填充骨缺损或用作骨替代材料,及其制备方法。

摘要

A prepared paste-like, plastically deformable, for construction / bone replacement, based on suspensions of ceramic material may be applied using an injection cannula, comprising a particulate component, porous, which is not readily soluble in water, and at least one liquid component, waxy or gel which is dissolved in water or alcohol, wherein the particulate component is not readily soluble in water is calcium phosphate and / or a bioactive glass ceramic material; the liquid component, waxy or gel which is soluble in water is an aqueous or alcoholic solution of an organic binder selected from the group of alginates, starches, polysaccharides, celluloses, modified celluloses, hyaluronic acids and their salts, gelatins, collagens , shellac, polyacrylic acids, aqueous or alcoholic solutions thereof, dextrans, polyethylene glycols, or mixtures thereof; the component is not readily soluble in water is 60-98% by weight, and the component dissolved in water or alcohol is 1-30% by weight, wherein the particles of component particles having a diameter in a range of sizes is substantially greater than a and smaller particle fagocitable the pitch diameter cannulas standard injection and the portion of the component dissolved in water or alcohol is 0.1-3% by weight, wherein the particles have a size in the range of 0.1 to 150 microns, pores in the range 0.01-50 microns and a polygonal shape with a rounded broken sintered structure.
机译:可以使用注射套管施加基于陶瓷材料的悬浮液而制备的糊状,可塑性变形的,用于建筑/骨置换的膏状物质,该注射套管包括不易溶于水的多孔的颗粒成分和至少一种液体成分溶于水或醇的蜡状或凝胶状,其中不易溶于水的颗粒成分是磷酸钙和/或生物活性玻璃陶瓷材料;溶于水的蜡状或凝胶状液体成分是选自海藻酸盐,淀粉,多糖,纤维素,改性纤维素,透明质酸及其盐,明胶,胶原蛋白,虫胶的有机粘合剂的水溶液或酒精溶液,聚丙烯酸,其水溶液或醇溶液,葡聚糖,聚乙二醇或其混合物;所述不易溶于水的组分为60-98重量%,并且溶于水或醇的组分为1-30重量%,其中直径在尺寸范围内的组分颗粒的颗粒明显大于a和较小的颗粒,可与螺距直径插管标准注射剂配合使用,并且该组分在水或酒精中的溶解比例为0.1-3%(重量),其中颗粒的尺寸在0.1到150微米范围内,孔的范围在0.01范围内-50微米,具有圆形破碎烧结结构的多边形形状。

著录项

  • 公开/公告号ES2524872T3

    专利类型

  • 公开/公告日2014-12-15

    原文格式PDF

  • 申请/专利权人 CURASAN AG;

    申请/专利号ES20070801298T

  • 申请日2007-08-30

  • 分类号A61L27/46;A61L27/50;

  • 国家 ES

  • 入库时间 2022-08-21 15:12:10

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