Arene complex Ru (II) oxime ligand with anticancer activity

摘要

Complexes arene Ru (II) oxime ligands with anticancer activity. # The present invention relates to complexes arene Ru (II) oxime ligands with anticancer activity, of formula (1) or (2), and which can be used in the treatment and / or prevention of cancer. # for (1) and (2), R1 to R6 may be halide, H, alkyl or aryl, functionalized or not. R {sub, 1} and R {sub, 2} can also be part of a saturated or unsaturated, carbon or heterocyclic 3 to 8 membered ring. P is a counter anion. n can be 0, 1 or 2. Z may be OH or O {sup, -}. R {sup, 1C} and R {sup, 2C} can be H, alkyl, alkenyl or linear or branched, cyclic, heterocyclic or acyclic alkynyl, each of these may or may not be differently substituted. They may also be part cyclic hydrocarbon or heterocyclic, saturated, unsaturated or aromatic 3 to 8 members. Y may be an amino or amido group, L is the linking group between X and Y.