pasteurelácea attenuated bacterium having a mutation in a virulence gene

摘要

An attenuated bacterium Pasteurella multocida, comprising a mutation in a gene represented by a polynucleotide sequence encoding a polypeptide FhaC (i) wherein the polynucleotide sequence hybridizes to the complement of SEQ ID NO: 19 under stringent conditions comprising such conditions a final wash in buffer comprising 2X SSC / 0.1% SDS at 35 ° C to 45 ° C, or (ii) wherein the polypeptide comprises an amino acid sequence at least 80% identical in the SEQ ID NO: 20, in which attenuation of the bacterium is caused by the mutation.