New activating peptides for the synthesis of extracellular matrix proteins and cosmetic compositions that comprise them

摘要

Peptide of general formula (I): R1- (AA) n-X1-Pro-X2-Gly-Pro-X3-X4- (AA) p-R2 in which X1 represents glycine or alanine or valine, X2 represents glycine or alanine or valine, X3 represents asparagine or lysine or glutamine or algim amino acid, X4 represents phenylalanine or tyrosine or algin amino acid, AA represents any amino acid and n and p are whole numbers between 0 and 2, R1 represents the primary amine function of the N-terminal amino acid, -NH2, in which one of the two hydrogen atoms can be substituted by either a saturated or unsaturated C1 to C30 alkyl chain, or by an acyl type group (R -CO-) in which the radical R is a saturated or unsaturated C1 to C30 alkyl chain and preferably a methyl, whether by an aromatic group of the benzoyl, tosyl or benzyloxycarbonyl type, R2 represents the hydroxyl group of the amino acid carboxyl function Cterminal, -OH, in which the hydrogen atom can be substituted by a C alkyl chain 1 to C30, or an NH2, NHY or NYY group, in which Y represents a C1 to C4 alkyl chain, said general formula sequence (I) being constituted from 5 to 11 amino acid residues and may be in the form of salts , characterized in that it corresponds to one of the following sequences: (SEQ ID No. 1) (SEQ ID No. 2) (SEQ ID No. 3) (SEQ ID No. 4) (SEQ ID No. 5) (SEQ ID No. 6): Ala-Pro-Ala-Gly-Pro-NH2: Val-Pro-Ala-Gly-Pro: Val-Pro-Gly-Gly-Pro-NH2: Gly-Pro-Ala-Gly-Pro: Gly- Pro-Ala-Gly-Pro-NH2: Lys-Gly-Ala-Pro-Gly-Gly-Pro-Asn-Tyr-N H2.