surgical implants to repair chondral defects

摘要

Process for preparing an implant for repairing a chondral defect, comprising: providing a mesenchymal stem cell (MSC); culturing MSCs in collagen medium containing collagen at a concentration of 1% to 10% w / v supplemented with transforming growth factor beta one (TGF-b1) for 7 to 21 days under conditions that allow the formation of a collagen matrix and differentiation of MSCs to give chondrocyte cell type, which are incorporated into the collagen matrix; which is characterized by chondrocyte cells secrete glycosaminoglycan type and the implant is free of gaps.