Procedure prenatal diagnosis in isolated fetal maternal blood cell

摘要

Procedure prenatal diagnosis in fetal cells isolated from maternal blood comprising the following steps: a) filtering a sample of pure or diluted maternal blood a filter porosity of between 6 and 15 microns, so that focus on the filter by size certain circulating cells, and particularly cells of fetal origin having a size of between 14 and 17 microns; b) analysis and characterization of retained cells isolated on the filter to search for the presence of a marker or immunological markers and / or cytological and / or genetic, to identify their epithelial nature and a presumption of its fetal or maternal origin; and individual cell or collection of epithelial cells which is supposed fetal origin; c) show, by genetic analysis, the fetal origin of a cell or cells of fetal origin course collected individually in step b; d) searching for genetic abnormalities in the genome or fetal origin whose genomes of cells has been shown in step c).